Guardians vs Yankees MLB Predictions, Odds & Best Bets (8/21)

Two leading teams in the American League, the Cleveland Guardians (73-52) and New York Yankees (73-53), are set to clash in the Bronx on Tuesday. If you’re interested in betting on today’s Guardians vs. Yankees game, you’ve landed in the right place.

Let’s stop wasting time, and get into my predictions and top MLB betting picks for tonight’s showdown.

2024 MLB Betting Picks Record: 76-90-1 (45.8%)

MLB Betting Today: Guardians vs Yankees (8/21)

Guardians vs Yankees Game Information

• Matchup: Cleveland Guardians (73-52, 35-32 Away) vs. New York Yankees (73-53, 32-28 Home)
• Venue & Location: Yankee Stadium (Bronx, NY)
• Date: Wednesday, Aug. 21, 2024
• Game Time: 7:05 p.m. ET
• How to Watch Guardians vs. Yankees: MLB.TV, Fubo, Prime Video

Guardians vs Yankees MLB Probable Pitchers

• Guardians: Joey Cantillo (3 starts — 0-2, 6.23 ERA)
• Yankees: Nestor Cortes (25 starts — 6-10, 4.20 ERA)

Yankees vs Guardians MLB Odds & Spread

Yankees vs. Guardians MLB odds are courtesy of BetOnline as of Wednesday, Aug. 21 at 11:15 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Guardians vs Yankees Run Line

• Cleveland Guardians +1.5 (-128)
• New York Yankees -1.5 (+108)

Yankees vs Guardians Over/Under

• Over 8 Runs (-120)
• Under 8 Runs (+100)

Guardians vs Yankees Moneyline

• Cleveland Guardians (+169)
• New York Yankees (-185)

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We offer a plethora of resources for baseball betting, including daily MLB odds, betting predictions, and expert picks. You can find all these resources below to kick-start your betting journey:

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Guardians vs Yankees MLB Betting Trends

• In its last 20 games as the underdog, Cleveland has a straight up record of 6-14.
• In their last 12 games against Cleveland, the Yankees have a straight-up record of 8-4.
• The Under was hit in four of Cleveland’s last six games.
• In five of the last six home games for the Yankees, the total has hit the Over.
• In eight of the last 12 matchups between the Guardians and the Yankees, the total score hit the Under.

Guardians vs Yankees Predictions & MLB Picks Today (8/21)

This week’s series was kicked off with a 9-5 victory by the Guardians over the Yankees last night. A decision on the winner required three additional innings, eventually leading to Cleveland scoring an impressive six runs in the 12th inning. This win marked their 73rd of the 2024 season.

The victory also signified the conclusion of a three-game losing streak for the Guardians. However, it’s worth noting that Cleveland only has a 6-10 straight up record in their last 16 games and has managed to secure consecutive road wins only once since the start of August. Thus, it’s still unclear whether the team’s most recent win was a fluke or not.

Concurrently, it seems like the Yankees are on a downward trajectory. Following a remarkable 13-5 SU streak from July 27 to Aug. 16, the Bronx Bombers have recently experienced three straight losses, being outscored 16-7 overall. This underscores the necessity for enhancements in both offensive and defensive play.

New York seems to have good luck on Wednesdays. The Yankees have won 13 out of their last 18 games that fell on this day, while the Guardians have only managed 2 victories in their last seven Wednesday games.

Things haven’t gone well for the Guardians in their recent Wednesday matchups. 

Another favorable statistic for the Yankees is their 8-4 SU record in their last 12 encounters with the Guardians. Moreover, New York has also triumphed over Cleveland in seven out of their last ten face-offs at Yankee Stadium.

We’ll have to wait and see if the current trend persists as LHP Nestor Cortes is set to start for the Yankees. Following a shaky performance over a month, Cortes made a comeback against the Chicago White Sox last week, taking down nine batters in seven innings without conceding a run, leading New York to a 4-1 victory. However, it’s noteworthy that he has also let in 12 earned runs from 17 hits in his most recent nine innings at Yankee Stadium.

Meanwhile, the Guardians are proceeding with rookie Left-Handed Pitcher (LHP) Joey Cantillo. The ex-2017 16th-overall pick’s Major League Baseball (MLB) career has had a rocky start, recording an 0-2 record and a 6.23 Earned Run Average (ERA) in his first three starts. He’s also given up four home runs in just 13 innings, which could prove detrimental against a Yankees team that ranks second in the MLB for average home runs per game.

Will veteran LHP Nestor Cortes lead the Yankees to victory? 

Tonight, we’re taking the Yankees to beat the Guardians. New York is hungry for revenge and a juicy opportunity is on the horizon based on Cantillo’s early struggles. Both teams are capable of winning, however, the Yankees clearly know how to beat the Guardians at home and I fully expect that trend to resume this evening.

With that in mind, I fully expect the 8-run total to be surpassed. For starters, the Over is an impressive 5-1 across New York’s last six home games (12.2 total runs per game). The Over is also 3-0 in the last three Guardians-Yankees matchups as the AL juggernauts averaged 13.0 total runs in those contests and just combined for 14 less than 24 hours ago.

Given the unpredictability of Cantillo and Cortes’ performances, it wouldn’t surprise me if we witness some spectacular action in the Bronx tonight.

Guardians vs. Yankees MLB Prediction: NYY wins

Best Guardians vs. Yankees Bet: o8 Total Runs (-120)

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Best Guardians vs Yankees MLB Player Prop (8/21)

If we’re expecting a ton of runs tonight, it’s a no-brainer to back an anytime Aaron Judge home run (+150) as the best Guardians vs. Yankees player prop.

Going into tonight’s clash, Judge tops the MLB with 45 home runs, with no signs of his bat losing its power. The six-time MLB All-Star has accumulated four home runs and a batting average of .452 in his last eight games (31 at-bats), recently hitting a home run against the Guardians. Moreover, he has succeeded in hitting a homer in consecutive encounters with Cleveland.

If you’re still not convinced, consider this: Judge has accumulated 12 home runs in 102 at-bats against left-handed starting pitchers. Given that Cantillo tends to give up a home run approximately every four innings, it’s easy to see why this proposition bet is highly appealing.